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Understand the principles of industrial fermentation and how it is crucial to develop the next generation of bio-based cleaner and greener fuels and consumer products. Gain valuable insights in biomanufacturing and propose a roadmap at the end of the build project for bio-ethanol production.
Industrial fermentation plays a significant role in reaching the U.S ambitious net-zero emissions economy by 2050 by enabling production of sustainable alternative to fuels and chemicals to reduce greenhouse gas emissions. The industry needs qualified scientists, associate scientists, research associates and engineers now more than ever.
In this Build Project, you will wear the hat of a Fermentation Scientist and develop a roadmap for bio-ethanol production using industrial fermentation. Under the supervision of an experienced industry expert, you will visualize various fermentation process parameters, understand the trends over time, and calculate metrics to identify the areas of improvement to increase key performance metrics like yield and productivity to make a process more economic and profitable. You will become familiar with different fermentation types, equipment, culture media, microbes etc. for different end applications. All this will happen in an environment that simulates the operations of a real bioprocess development team.
· Understand the concept of fermentation and its evolution over the years into industrial fermentation to manufacture bio-based fuels and chemicals.
· Familiarize with the types of fermentations, equipment, culture media, host micro-organisms.
· Visualize, analyze and interpret simulated fermentation data in a ms-excel environment and identify and calculate the key performance indicators.
· Develop critical thinking, analytical, presentation and communication skills.
Get to know the Project Leader and other students, ask questions about the project requirements, prepare your workspace.
Understand the importance of biomanufacturing in today’s climate change scenario. The contributions of fermentation science in aiming towards the ambitious net-zero emissions goal. Familiarize with the corporate structure of bioprocess teams within U.S. based biotech companies, where do you fit in and what are the most desirable skills. At the end of this session, we will talk about the final project and how you can start building your final project from the very beginning of this build project.
Learn about Fermentation science and its transition into Industrial Fermentation. What are the different types of fermentation and their applications. Familiarize yourself with the importance and regulation of microbial culture to achieve desired applications.
This session takes a deeper dive into flow of operations and different process parameters like dissolved oxygen, pH, temperature, agitation etc. of an actual industrial fermentation process. At the end of this session students should start formulating their final project.
Continue digging deeper by learning about various microbes used in fermentation. How to formulate culture media, understand growth curves, calculate growth rates and timing of growth for maximizing productivity.
With the basic understanding of industrial fermentation from all the earlier sessions, students will now look at some dummy fermentation data for the same parameters that they studied in session 4 to get an idea of how real fermentation data looks like. This interesting session is a transition from theory to practical application.
In this session students will step into the shoes of a Fermentation Scientist, using the raw data to calculate Key Performance Indicators or KPIs that can be used to draw inferences of whether an experiment was successful or not and learn about the strategies to improve process metrics. By the end of this session students are expected to finish their final deliverable.
In this session students will present their project learnings and propose a mock biorefinery model for bio-ethanol production as their final deliverable to the rest of the class, receive feedback and understand future avenues for continued learning in the field.
· Knowledge of arithmetic: basic operations like addition, subtraction, multiplication and division along with an understanding of fractions, decimals and percentages
· Knowledge of algebra: Basic concepts such as equations, inequalities, functions and graphing
· Basic understanding of general chemistry including some understanding of chemical reactions, solutions, concept of pH, basic thermodynamics.
· An understanding of unicellular organisms like bacteria and yeast
· An interest in biotech, chemical processes
· Critical thinking and research mindset needed for the deliverables of various sessions
· Curiosity and willingness to learn
· Communication: Should be willing and able to express themselves
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Priya Sengupta is a Chemical Engineering Fellow at Open Avenues Foundation, where she works with students leading projects in Chemical Engineering.
Priya is a Fermentation Scientist at Lygos where she works on early-stage and late-stage process development of bioproduction of organic acids via fermentation.
Priya has 7 years of experience in the field of fermentation. Prior to that she was working as a Fermentation Scientist and Team Lead at Huue where she was leading early stage process development of bio-based textile dye indigo.
She holds a PhD degree in Chemical and Environmental Engineering.
A fun fact about Priya: She can speak 8+ languages spoken in India.