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Research modern liquid chromatography techniques (HPLC) and help improve the method for separation and resolution of oligonucleotides.
Oligonucleotides are synthetically produced biomolecules that have proven to be crucial for gene editing therapies. Biotech companies put a lot of time and effort in optimizing and developing groundbreaking analysis techniques for these molecules; purity assessment being one of the most significant ones. High performance liquid chromatography (HPLC), is one of the tools almost every research team uses to assess and characterize the constituents found in a compound. Knowing this technique becomes a very important skill even for entry-level jobs.
In this Build Project, you'll wear the hat of an Analytical Development Scientist and help optimize a method for purity/integrity assessment of oligonucleotides through RP-IP HPLC. Under the supervision of an experienced Build Fellow, you'll become proficient in navigating scientific literature and building your own conclusions and course of actions in the development of this method. You'll learn the science behind liquid chromatography and how biomolecules such as RNA behaves in such. You will also be able to appreciate role that oligonucleotides play in gene editing therapies; a rising focus for biotech companies. All this will happen in an environment that simulates the operations of a real Analytical Development team.
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Juan Carlos Garcia-Prieto is a Chemistry Global Talent Fellow at Open Avenues, where he works with students leading projects in Chemistry.
Juan Carlos Garcia-Prieto is an Associate Scientists, Analytical Development at Tome Biosciences where he works on developing and optimizing assays for the quantitation and characterization of biomolecules involved in gene editing therapies.
Juan Carlos Garcia-Prieto has 3 years of experience in Analytical Development.
Prior to joining Tome, Juan Carlos Garcia-Prieto worked at Moderna analyzing and characterizing all the raw materials used to produce vaccines, as well as any other biomolecule used for research purposes.
He holds a degree in Chemistry.
A fun fact about Juan Carlos Garcia-Prieto: He has a 2yo French Bulldog named Bruno.