Your application

Please complete the following fields to be considered for this project.

Please fill in this required field.
Please fill in this required field.
Please fill in this required field.
Please fill in this required field.
Please fill in this required field.
How much commitment will you have to this project?
Please fill in this required field.
Are you available to dedicate 1-2 hours per week to the Build Project?
Please fill in this required field.
Your application has been 
successfully submitted!
Explore more projects
Close
There was an error submitting your form. Please try again later or contact us.
Oops! Something went wrong while submitting the form.

This project is no longer accepting applications. Subscribe to our newsletter to be notified of new projects!

Get updates
Quantify Cytokine Release to Functionally Characterize CAR T-cells Targeting Tumor Antigens 
Sai Valli Srujana Namburi
Sai Valli Srujana Namburi
Get updates
Register today
Apply now

Quantify Cytokine Release to Functionally Characterize CAR T-cells Targeting Tumor Antigens 

Learn the biology of CAR T-cells and cytokines with a major focus on quantifying cytokine secretion in response to cancerous tumors.

Register today
Apply now
Fridays
 at
10:00
A.M.
 ET /
7:00
A.M.
PT
8 weeks, 2-3 hours per week
Intermediate
No experience required
No experience required
Some experience required
Degree and experience required

Description

Cytokines are cell signaling proteins and are released by the CAR-T cells upon engagement with tumor antigens. So, measuring cytokines release is one of the most often used techniques in tumor research. This data is often critical for Investigational New Drug (IND) applications to the FDA. In this Build Project, you'll wear the hat of a Research Associate and quantify a certain set of cytokines to evaluate the functional profile of CAR T-cells before their clinical application. Under the supervision of an experienced Build Fellow, you'll learn how to process the raw data for visual and quantitative analysis using statistical software like MS Excel and GraphPad Prism. You'll also develop skills for drawing meaningful conclusions from the analysis you perform.

Session timeline

  • Applications open
    May 27, 2024
  • Application deadline
    June 23, 2024
  • Project start date
    Week of July 8, 2024
    Week of
    July 8, 2024
  • Project end date
    Week of

What you will learn

  • Knowledge about CAR-T cell therapy and the importance of cytokines
  • Cytokine-release assay design and data analysis
  • Data compilation and scientific presentation
Build Projects are 8-week experiences that operate on a rolling basis. Selected participants engage in weekly live workshops with a Build Fellow and 2-15 other students.

Project workshops

1
Introduction
2
Literature review
3
Journal club
4
Experiment design
5
Data analysis
6
Data interpretation
7
Build final projects
8
Presentations

Prerequisites

  • Basic knowledge of biology: you should understand the concept of cells, immune system and cancer. 
  • Basic knowledge of MS Office: you should be able to navigate through MS Excel and MS PowerPoint. 

Sign up today

Get access to all of our Build projects, including this one, by creating your Build account!

Register today
Log in

Apply to

Sai Valli Srujana

's project today!

Get started by submitting your application.

Apply now

Stay updated!

Subscribe to our newsletter to be notified when projects reopen!

Please fill in this required field.
By clicking “Subscribe” you agree to our Terms of Services and Privacy Policy.

Thanks for subscribing!

We'll notify you when projects reopen. In the meantime, you can explore our resources and learn more about our Fellows.

Discover our articles
There was an error submitting your form. Please try again later or contact us.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
About the expert

Sai Namburi is a Molecular Biology Build Fellow at Open Avenues, where she works with students leading projects in cell biology. She works for a cell therapy company on the development of CAR T- Cell therapies for cancer. Sai has 6 years of experience in pre-clinical research. She has research experience in both academic research institutions and pharmaceutical industries. Sai holds a Master’s degree in Microbiology and Immunology. A fun fact about Sai is that you can find her biking on CA-1 if she isn't at work.

Visit
Sai Valli Srujana
's Linkedin
More like this Project
No items found.