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Learn the biology of CAR T-cells and cytokines with a major focus on quantifying cytokine secretion in response to cancerous tumors.
Cytokines are cell signaling proteins and are released by the CAR-T cells upon engagement with tumor antigens. So, measuring cytokines release is one of the most often used techniques in tumor research. This data is often critical for Investigational New Drug (IND) applications to the FDA. In this Build Project, you'll wear the hat of a Research Associate and quantify a certain set of cytokines to evaluate the functional profile of CAR T-cells before their clinical application. Under the supervision of an experienced Build Fellow, you'll learn how to process the raw data for visual and quantitative analysis using statistical software like MS Excel and GraphPad Prism. You'll also develop skills for drawing meaningful conclusions from the analysis you perform.
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Sai Namburi is a Molecular Biology Build Fellow at Open Avenues, where she works with students leading projects in cell biology. She works for a cell therapy company on the development of CAR T- Cell therapies for cancer. Sai has 6 years of experience in pre-clinical research. She has research experience in both academic research institutions and pharmaceutical industries. Sai holds a Master’s degree in Microbiology and Immunology. A fun fact about Sai is that you can find her biking on CA-1 if she isn't at work.