Introduction

Hello everyone, my name is Gauri Kulkarni. I embarked on my academic journey in India with a clear vision and passion for the research industry. While my peers aspired to become doctors, I knew that my calling lay in the world of scientific exploration and discovery. This led me to pursue a Bachelor of Engineering in Instrumentation and Control with a major in Biomedical Engineering.

During my undergraduate years, I developed a solid understanding of engineering principles. In my final year, I had the incredible opportunity to work on a project aimed at developing a device to detect Parkinson’s disease. This experience ignited a deep interest in neurodegenerative diseases, propelling me towards a future focused on understanding and finding solutions for these conditions.

To further my education and delve deeper into the field of Biomedical Engineering, I knew that pursuing a Master’s degree was essential. I soon realized that gaining admission to reputable schools in the United States without work experience would be challenging. Determined to acquire practical skills and knowledge, I decided to work for a year in a pharmaceutical company in India. This invaluable experience provided me with hands-on exposure to a wet lab environment and allowed me to work with cutting-edge analytical lab equipment.

In 2018, I made the decision to pursue my Master’s degree in Biomedical Engineering in the United States. I was accepted into Binghamton University, where I immersed myself in my studies. With a particular focus on neurodegenerative diseases, I continued my research, eager to contribute to the growing body of knowledge and make a tangible impact in this field. I focused on detecting Alzheimer’s disease using digital biomedical engineering techniques. This research not only deepened my understanding of the field but also exposed me to various programming languages and software tools, enhancing my technical skills.

During my Master’s program, I also had the opportunity to collaborate with a PhD student. This collaboration sparked my initial interest in the field of oncology, as I witnessed the profound impact that research could have on improving cancer treatments and patient outcomes.

Upon completing my Master’s degree, I secured a job as a biomedical engineer. In this role, I primarily worked in process development, applying the engineering principles I had learned throughout my education. After a few months, I realized that my true passion lay in the research aspects of my work, particularly in the field of immuno-oncology.

Motivated by my passion for research and the desire to contribute to cutting-edge advancements in cancer treatment, I made the decision to join as a research associate in a biotechnology industry company. Here, I have been fortunate to work on groundbreaking research aimed at developing transformative cancer treatments for patients. Along the way, I have gained valuable skills, both technical and interpersonal, that have furthered my growth as a researcher.

Throughout my journey, I have come to realize that my training in engineering has been instrumental in my ability to excel in the research field. The problem-solving mindset, analytical thinking, and attention to detail that I developed during my engineering education have proven to be invaluable assets in my research endeavors.

As I look back on my experiences and the skills I have acquired, I am grateful for the opportunities that have shaped my path. With each step, my passion for research and dedication to improving patient outcomes in the field of immuno-oncology continue to drive me forward. From my beginnings in India to pursuing my passion in a foreign land, I have encountered numerous challenges along the way. But my determination and unwavering commitment to making a difference have propelled me forward.

Chemical Engineering Fellow

career options

The biotechnology and biomedical engineering fields offer a wide range of career options for individuals interested in applying science and technology to improve human health and advance medical research. These fields involve the use of biological systems, engineering principles, and technology to develop innovative solutions and products. The different careers offer opportunities for research, development, manufacturing, and consulting in various sectors such as pharmaceuticals, biotechnology companies, research institutions, and medical device companies.

The field of biotechnology and biomedical engineering is vast, with many diverse career paths. A few options have been described below, but these only encompass some career paths.

1
Process Engineer
2
R&D engineering
3
Biotechnology Engineer
4
Consultant
5
Project Manager
6
Safety Engineer

Chemical Engineering Fellow

 skills

What are the main hard skills you use on a daily basis in your current job?

1
Process Scale-Up

Aseptic techniques in the biotechnology industry are essential for maintaining the sterility and integrity of biopharmaceutical products. These techniques involve creating a sterile environment, ensuring personnel are properly trained, sterilizing equipment, and performing aseptic manipulations. Regular monitoring and validation are also crucial to ensure the effectiveness of these techniques. By implementing aseptic techniques, biotechnology companies can prevent contamination and ensure the quality and safety of their products, meeting regulatory requirements and maintaining product integrity.

2
Statistical Analysis and Design of Experiments:

Process optimization often involves statistical analysis and the application of DoE methodologies. I have learnt about this during my ChemE courses and seminars from JMP. During my process development, I usually design experiments, collect and analyze data, and use statistical tools like JMP to identify key process parameters, optimize conditions, and ensure reproducible purification processes.

3
Filtration and Separation Techniques

Proficiency in filtration and separation techniques is vital for separating solids, liquids, and gases from biomolecular solutions. I use these common separation techniques such as depth filtration, tangential flow filtration (TFF), centrifugation, and membrane filtration very frequently in downstream process development to separate biomass from fermentation broth. I have learnt about these techniques from ChemE courses and had hands-on experience during my job here at Lygos

4

Data analysis skills are crucial in biotechnology and biomedical engineering, allowing for interpreting and extracting insights from complex datasets. Proficiency in statistical analysis, knowledge of data analysis techniques, and familiarity with software and statistical packages commonly used in these fields are essential for effective data analysis.

5

What are the main soft skills you use on a daily basis in your current job?

1
Communication skills

Effective communication is vital for collaborating with cross-functional teams, presenting findings, and sharing process updates. In my current job, I usually need to explain complex technical concepts in a clear and concise manner to colleagues with varying levels of technical expertise. There is no definite method to learn communication skills, but they are mostly learned through practice, experience, and seeking feedback from other colleagues and supervisors.

2
Project Management

Process development projects usually involve multiple tasks, timelines, and stakeholders, so having basic project management skills has helped me organize my work, set priorities, and meet deadlines. These skills were learnt through coursework, workshops, or practical experience. The application I often used at my job is Smartsheet, which has been very helpful for me when planning experiments, coordinating resources and ensuring that projects progress smoothly and on schedule


3
Adaptability and Flexibility

The biotech industry is rapidly evolving, with new technologies and methodologies constantly emerging. I usually need to adapt to changing circumstances, technologies, and project requirements, especially when working in a start-up environment. Because of that, I always try to be exposed to diverse projects, learning experiences, and staying updated on industries trend

4
5

Truyen

’s personal path

Tell us about your personal journey in

Chemical Engineering Fellow

:

I graduated from UC Berkeley in May 2020 and it was during the time when the pandemic just started, so it was particularly challenging to find jobs at that time. Everything had to be done online, and there was no career/job fair to go to meet employers. During that time, I did about 50-100 applications, mostly on LinkedIn and Indeed.com, and I did not get many responses until 3 months after I graduated. Since my working visa was expiring, I already booked a flight ticket home. Luckily two weeks before my flight, I got an interview invitation for a process development engineer position at Lygos, in which I did an online interview with 3 people and an in-person tour. I got accepted in the next few days and my life has changed since then. Working at a start-up was incredibly challenging since I had to do everything myself from building equipment, organizing working space, ordering new equipment/materials, planning experiments, etc. However, it was a good learning environment for a new graduate since I could develop diverse types of skills that you cannot have, working in big companies. Also, having a good mentor and colleagues is immensely helpful, so that is why I am still working here at Lygos after 3 years.

What would you tell your younger you regarding building your current career?

I would tell my younger me to go out and explore more instead of just focusing on studying at university. A good GPA is nice to have but not a requirement to land a good job, but instead relevant experience and connections are more important because after your first job, no employer will rate your GPA highly anymore. Apply to different jobs, internships, club activities to gain more experience, connections, and develop both social and technical skills because these skills will not only help you get accepted into a job but will help you succeed in it and open to more opportunities that will bring you closer to your dream jobs.

Final thoughts & tips

To improve your chance of landing a job, take advantage of all the resources available to you at schools and your surroundings. It is always good to have a dream job, something to aim for in your career, but be realistic and open to new opportunities. Go to career fairs, talk to companies, take part in club activities, email alumni, talk to your professors, etc. are different ways you can use to explore more about different industries. Once you understand what you are interested in, come up with a list of skills that may be needed for that industry and start working on it. Also, apply to internships, research positions or part-time jobs during the summers because it will give you an edge compared to others with no experience, especially in engineering positions.

Truyen Le

Truyen Le

Chemical Engineering Fellow
Open Avenues Foundation
Open Avenues Foundation

Hey everyone, my name is Truyen Le and I’m originally from Viet Nam. I came to the US in 2012 to pursue my bachelor’s degree in chemical engineering at University of Minnesota (UofM). In 2017, I was accepted to a master's program in chemical engineering at University of California, Berkeley and the Bay Area was one of the largest technology hubs in the US, so I decided to move there after 6 years living in Minnesota. After graduating from U.C. Berkeley, I have been working as a process development engineer at Lygos to develop downstream processes for purification of specialty chemicals obtained from fermentation.

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